John Holmes, PhD, Core Co-Lead

John H. Holmes, PhD, is Co-Lead on the UPenn PRC Evaluation Core. Dr. Holmes is Associate Professor of Medical Informatics in Epidemiology at HUP.  He has been with the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania since 1982, holding a variety of research staff positions.  He joined the standing faculty at Penn in 2001.  He holds appointments in the Graduate Groups in Biostatistics and Epidemiology and in Public Health and a secondary appointment in the School of Nursing.   He directs the doctoral training program in epidemiology at the University of Pennsylvania.  Dr. Holmes’ research interests are focused on several areas in medical informatics.  Specifically, his interests are in evolutionary computation and machine learning approaches to knowledge discovery in clinical databases (data mining), interoperable information systems infrastructures for epidemiologic surveillance, clinical decision support systems, semantic analysis, and information systems user (physician and patient) behavior.  Dr. Holmes is an expert in human-computer interaction and the sociotechnical aspects of computing in healthcare environments by virtue of training at the doctoral level in systems ethnography and experience in academic health centers. He is particularly interested in methods for incorporating informatics with patient safety in the medical school curriculum and in informatics training programs. Dr. Holmes is principal investigator on an NCI-funded project in the Penn Center for Population Health and Health Disparities, that seeks to investigate informatics-based approaches to reducing disparities in shared decision making by African-American men and their health care providers with respect to prostate cancer screening.   He is principal investigator on a project funded by the National Library of Medicine to develop and evaluate new text mining tools to discover evidence of adverse events and interactions associated with the use of herbal and nutritional supplements, as reported by participants in online health discussion boards, blogs, and chat rooms. Dr. Holmes is a Fellow of the American College of Medical Informatics, a member of the American College of Epidemiology, a Senior Fellow of the Leonard Davis Institute of Health Economics, and a Senior Fellow of the Center for Public Health Initiatives at Penn.  He is involved in several epidemiology and informatics competencies activities, including the Association of American Medical Colleges-Howard Hughes Medical Institute Scientific Foundation for Future Physicians Committee and the AAMC Medical School Objectives Project Expert Panel on Behavioral and Social Sciences. To learn more, visit: